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Note: "Merck & Co., Inc." has its headquarters in Whitehouse Station, NJ, USA and operates in most countries outside the U.S. as Merck Sharp & Dohme. "Merck KGaA" has its headquarters in Darmstadt, Germany; "Bayer Schering Pharma AG", with its headquarters in Berlin, Germany, is a division of "Bayer HealthCare AG", which has its headquarters in Leverkusen, Germany; "Schering-Plough" has its headquarters in Kenilworth, NJ, USA. Merck & Co. Inc., Merck KGaA, Bayer HealthCare and Schering-Plough are all members of the IFPMA.
INVESTMENT DRIVERS Our top picks for 2004 are Shionogi and Eisai, ahead of what will likely be another year of treading water for the Japanese pharma industry. While some valuations seem tempting, we recommend an equal weight with some dry powder should any upside surprise opportunities develop. Substantive "restructuring" of this moribund sector may be on the horizon if Yamanouchi Fujisawa create a smart merger and set off a trend. Younger managements are taking an upper hand, while `daiko henjo selling pressure' is waning, thus stabilizing an external negative. Inefficiencies in operations persist, and the outlook for earnings growth stagnates. Globalization is critical, but substantial investments are needed even by Takeda, Yamanouchi, Sankyo, Eisai, and Fujisawa. Few others have a chance beyond Japan. Regulatory reforms may take years, but will cause more dull rather than sharp pain near term. The April `04 price cuts will likely be modest, while efforts to speed new drug approval may finally bear fruit. A generic threat is the biggest negative looming long-term. Interesting pipeline drugs - MRA, capravirine, TAK-375, Vesicare, and DX-8951f, have potential to create positive surprise, though valuations reflect much of their promise. Mevalotin, Levaquin, Lupron, and Prevacid are completing their life cycle and pose major challenges for the originators. TOP PICKS FOR 2004 Eisai - Global growth of Aricept and Aciphe drives what is the third highest growth rate in the Japanese pharma sector. Expansion of the US sales force will be an important contributor to this growth; as plans to partner CNS drugs in the region progress including the recently in-licensed rasagiline for Parkinson's ; , Eisai will maximize its sales force productivity and prepare for its next major products. Shionogi - Crestor should drive industry high long term growth, supported by recent new product launches and promising late stage pipeline products. Shionogi's successful R&D organization is poised to be recognized as one of the better ones in Japan, as seen in the robust deal done with AstraZeneca for Crestor, the GlaxoSmithKline JV, and the partnership with Pfizer for S-1153 capravirine ; . Table 1 Outlook 2004 UNIVERSE RANKING JAPAN PHARMA and actos.
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