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Oral contraceptive products may be affected. Healthcare providers should refer to the label of the individual anti-HIV protease inhibitor for further drug-drug interaction information. Drug-Food Interactions Interactions with food have not been established. Drug-Herb Interactions Herbal products containing St. John's Wort hypericum perforatum ; may induce hepatic enzymes cytochrome P450 ; and p-glycoprotein transporter and may reduce the effectiveness of contraceptive steroids. This may also result in breakthrough bleeding. Drug-Laboratory Test Interactions Laboratory Tests Results of laboratory tests should be interpreted with the knowledge that the patient is taking an oral contraceptive. The following laboratory tests are modified: A. Liver Function Tests Aspartate serum transaminase AST ; - variously reported elevations Alkaline phosphatase and gamma glutamyl transferase GGT ; - slightly elevated. Coagulation Tests Minimal elevation of test values reported for such parameters as prothrombin and Factors VII, VIII, IX and X. Thyroid Function Tests Protein binding of thyroxine is increased as indicated by increased total serum thyroxine concentrations and decreased T3 resin uptake. Lipoproteins Small changes of unproven clinical significance may occur in lipoprotein cholesterol fractions. Gonadotropins LH and FSH levels are suppressed by the use of oral contraceptives. Wait two weeks after discontinuing the use of oral contraceptives before measurements are made. Glucose tolerance Oral glucose tolerance remained unchanged or was slightly decreased, for instance, brtehine use.

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The unapproved use of terbutaline also known as bdethine or bricanyl ; has most recently been linked to an increase in birth injuries and maternal side effects and bricanyl.
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