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OpenEye FILTER is used to calculate biological and chemical properties of the compounds that are related to their potential effectiveness as drugs A tumor cell line is selected. The activity results for all the compounds in the DTP database in the given range are extracted from the PostgreSQL database. 121. Hughes, K.M., Lang, J.C.T., Lazare, R., Gordon, D., Stanton, S.L., Malone-Lee, J., et al. Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers. Xenobiotica, 22: 859, 1992. Ouslander JG, Blaustein J, Connor A et al. Pharmacokinetics and clinical effects of oxybutynin in geriatric patients. J Urol 140: 47, 1988 Douchamps, J., Derenne, F., Stockis, A., Gangji, D., Juvent, M., and Herchuelz, A.The pharmacokinetics of oxybutynin in man. Eur J Clin Pharmacol, 35: 515, 1988. Kachur, J.F., Peterson, J.S., Carte, r J.P., Rzeszotarski, W.J., Hanson, R.C., and Noronha-Blob, L. R and S enantiomers of oxybutynin: pharmacological effects in guinea pig bladder and intestine. J Pharmacol Exp Ther, 247: 867, 1988. Nilvebrant L, Andersson K-E, Mattiasson A. Characterization of the muscarinic cholinoceptors in the human detrusor. J Urol 134: 418, 1985. Nilvebrant L, Sparf B. Dicyclomine, benzhexol and oxybutynin distinguish between subclasses of muscarinic binding sites. Eur J Pharmacol 123: 133, 1986. Norhona-Blob, L., and Kachur, J.F. Enantiomers of oxybutynin: in vitro pharmacological characterization at M1, M2 and M3 muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs. J Pharmacol Exp Ther 256: 562, 1991. Dmochowski, R.R., Davila, G.W., Zinner, N.R., Gittelman, M.C., Saltzstein, D.R., Lyttle, S., et al. ; For The Transdermal Oxybutynin Study Group. Efficacy and safety of transdermal oxybutynin in patients with urge and mixed urinary incontinence. J Urol, 168 2 ; : 580, 2002. 129. Yarker, Y.E., Goa, K.L., and Fitton, A. Oxybutynin - A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability. Drugs Aging, 6: 243, 1995 Andersson, K.-E., and Chapple, C.R. Oxybutynin and the overactive bladder. World J Urol, 19 5 ; : 319, 2001. 131. Amarenco, G., Marquis, P., McCarthy, C., and Richard, F. Qualit de vie des femmes souffrant dmpriosit mictionelle avec ou sans fuites: tude prospective aprs traitement par oxybutinine 1701 cas ; . Presse Medicale, 27: 5, 1998. Ouslander, J.G., Schnelle, J.F., Uman, G., Fingold, S., Nigam, J.G., Tuico, E., et al. Does oxybutynin add to the effectiveness of prompted voiding for urinary incontinence among nursing home residents? A placebo-controlled trial. J Geriatr Soc, 43: 610, 1995. Szonyi, G., Collas, D.M., Ding, Y.Y., and Malone-Lee, J.G. Oxybutynin with bladder retraining for detrusor instability in elderly people: a randomized controlled trial. Age Aging, 24: 287, 1995 Szollar, S.M., and Lee, S.M. Intravesical oxybutynin for spinal cord injury patients. Spinal cord, 34: 284, 1996 Kim, Y.H., Bird, E.T., Priebe, M., and Boone, T.B. The role of oxybutynin in spinal cord injured patients with indwelling catheters. J Urol, 158: 2083, 1996 Baigrie, R.J., Kelleher, J.P., Fawcett, D.P., and Pengelly, A.W. Oxybutynin: is it safe? Br J Urol, 62: 319, 1988. Jonville, A.P., Dutertre, J.P., Autret, E., and Barbellion, M. Effets indsirables du chlorure doxybutynine D9tropan ; . Therapie 47: 389, 1992. Hussain RM, Hartigan-Go K, Thomas SHL et al. Effect of oxybutynin on the QTc interval in elderly patients with urinary incontinence. Br J Clin Pharmacol 37: 485P, 1994 Appell, R.A., Chancellor, M.B., Zobrist, R.H., Thomas, H., and Sanders S.W. Pharmacokinetics, metabolism, and saliva output.

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