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The available knowledge concerning the relationship of fluvoxamine and the cyp450 enzyme system has been obtained mostly from pharmacokinetic interaction studies conducted in healthy volunteers, but some preliminary in vitro data are also available.
You are covered for emergency and urgent care when you are temporarily outside Inter Valley's service area. Whenever possible, call our toll-free numbers, 800 ; 251-8191 in California, 800 ; 255-6882 outside California, before seeking treatment. If this is not possible, you must notify the Plan about your treatment within 48 hours or as soon as possible. REMINDER: Inter Valley's tollfree numbers are printed on the back of your Health Plan ID Card. Don't leave home without it.
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Principal investigator: eugene cheng, md funding agent: johnson & johnson pharmaceutical research & development this study is designed to confirm that epoetin alfa decreases the need for transfusions and to determine if there is decrease in mortality in those patients receiving epoetin alfa.
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Attachment 1. ORDINANCE NO. 1095 AN ORDINANCE OF THE CITY COUNCIL OF THE CITY OF UKIAH ADOPTING CHAPTER 8 IN DIVISION 6 OF THE UKIAH CITY CODE, ENTITLED: "MEDICAL MARIJUANA DISPENSARIES." The City Council of the City of Ukiah hereby ordains as follows: SECTION ONE. Chapter 8 is hereby added to Division 6 of the Ukiah City Code to read as follows: Chapter 8 5700: Medical Marijuana Dispensaries FINDINGS AND PURPOSE and folic, for example, fluvoxamine 100mg.
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Research Committee Report - Pierre Blanger - Dr. Blanger reported that a survey had recently been forwarded to each Dean regarding research activities in their faculty and the survey also sought information on how AFPC can help support academic pharmacy and pharmaceutical science research. 82.
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Also found to be stable during aging. The authors note that these findings reinforce the need for researchers to carefully consider metabolic differences, environmental conditions, genetic background, and species when attempting to extrapolate regulatory mechanisms from animal models to humans.
173. Wakelin JS. Fluvoaxmine in the treatment of the older depressed patient; double-blind, placebo-controlled data. Int Clin Psychopharmacol 1986; 1: 221-30. Charney DS, Price LH, Henninger GR. Desipramine-yohimbine combination treatment of refractory depression: Implications for the -adrenergic receptor hypothesis of antidepressant action. Arch Gen Psychiatry 1986; 43: 1155-61. Cournoyer G, De Montigny C, Ouellette J, et al. A comparative double-blind controlled study of imipramine and amitriptyline in major depression: lack of correlation with 5-hydroxytryptamine reuptake blockade. J Clin Psychopharmacol 1987; 7: 385-93. Davidson J, Miller R, Van-Wyck FJ. A double-blind comparison of bupropion and amitriptyline in depressed inpatients. J Clin Psychiatry 1983; 44: 115-7. Fava M, Rosenbaum JF, McGrath PJ, Stewart JW, Amsterdam JD, Quitkin FM. Lithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled study. J Psychiatry 1994; 151: 1372-4. Feet PO, Larsen S, Robak OH. A double blind study in out-patients with primary non-agitated depression treated with imipramine in combination with placebo, diazepam or dixyrazine. Acta Psychiatr Scand 1985; 72: 334-40. Feldmann HS, Denber HCB. Long-term study of fluvoxamine: a new rapid-acting antidepressant. Int Pharmacopsychiatry 1982; 17: 114-22. Guelfi JD, Dreyfus JF, Pichot P. Fkuvoxamine and imipramine: results of a long-term controlled trial. Int Clin Psychopharmacol 1987; 2: 103-9. Klieser E, Lehmann E. Experimental examination of trazodone. Clin Neuropharmacol 1989; 12: S18-24. 182. Kupfer DJ, Frank E, Perel JM, et al. Five-year outcome for maintenance therapy in recurrent depression. Arch Gen Psychiatry 1992; 49: 769-73. Lingjaerde O, Bratfos O, Bratlid T, Haug JO. A double-blind comparison of zimelidine and desipramine in endogenous depression. Acta Psychiatr Scand 1983; 68: 22-30. Nelson JC, Mazure CM, Bowers MB Jr, Jatlow PI. A preliminary, open study of the combination of fluoxetine and desipramine for rapid treatment of major depression. Arch Gen Psychiatry 1991; 48: 303-7. Ontiveros A, Fontaine R, Elie R. Refractory depression: the addition of lithium to fluoxetine or desipramine. Acta Psychiatr Scand 1991; 83: 188-92. Reynolds CF III, Frank E, Perel JM, et al. Treatment of consecutive episodes of major depression in the elderly. J Psychiatry 1994; 151: 1740-3. Zajecka JM, Jeffries H, Fawcett J. The efficacy of fluoxetine combined with a heterocyclic antidepressant in treatment-resistant depression: a retrospective analysis. J Clin Psychiatry 1995; 56: 338-43. Bowden CL, Schatzberg AF, Rosenbaum A, et al. Fluoxetine and desipramine in major depressive disorder. J Clin Psychopharmacol 1993; 13: 305-10. de Wilde J, Spiers R, Mertens C, Bartholome F, Schotte G, Leyman S. A double-blind, comparative, multicentre study comparing paroxetine with fluoxetine in depressed patients. Acta Psychiatr Scand 1993; 87: 141-5. de Wilde JE, Mertens C, Wakelin JS. Clinical trials of fluvoxamine vs chlorimipramine with single and three times daily dosing. Br J Clin Pharmacol 1983; 15: 427S-31S. Guillibert E, Pelicier Y, Archambault JC, Chabannes JP, Clerc G. A double-blind, multicentre study of paroxetine versus clomipramine in depressed elderly patients. Acta Psychiatr Scand 1989; 80: 132-4. Keegan D, Bowen RC, Blackshaw S, et al. A comparison of fluoxetine and amitriptyline in the treatment of major depression. Int Clin Psychopharmacol 1991; 6: 117-24. Reynaert C, Parent M, Mirel J, Janne P, Haazen L. Moclobemide versus fluoxetine for a major depressive episode. Psychopharmacology Berl ; 1995; 118: 183-7. Stewart JW, Quitkin F, Liebowitz MR, McGrath PJ, Klein DF. Efficacy of desipramine in mildly depressed patients: A double- blind, placebo-controlled trial. Psychopharmacol Bull 1981; 17: 136-7. Tignol J, Stoker MJ, Dunbar GC. Paroxetine in the treatment of melancholia and severe depression. Int Clin Psychopharmacol 1992; 7: 91-4 and geodon.
Nederlandse Vereniging voor Microbiologie Commissie Wetenschap van de Nederlandse Vereniging voor Medische Microbiologie Commissie NWO Grote Investeringen Commissie Meticilline Resistente Staphylococcus Aureus MRSA ; van de Gezondheidsraad. Adviescommissie Centrum Infectieziektenbestrijding RIVM jury Yourrassowsky Foundation voor toekenning prijs 2006 ; Board SIOP, International Society of Paediatric Oncology American Society of Hematology European Society of Haematology Koninklijke Nederlandse Maatschappij Geneeskunst wetenschappelijke Raad Ontwikkelingssamenwerking Koningin Wilhelmina Fonds Raad van Advies CIS: Centrum voor Internationale Samenwerking Vrije Universiteit Raad van Advies ICHD: International Course Public Health Development, een samenwerkingsverband tussen VU, UvA en Kon Instituut voor de Tropen Adviesraad Stichting Medische Noodhulp Indonesi PODC: Committee for Paediatric Oncology in Developing Countries Advisory Board VIVA foundation for children with cancer, Singapore Wetenschappelijke Adviesraad Estellafonds Stichting Ontwikkelings samenwerking VUmc "MMM" NVvR Dutch Society of Radiology ; met lidmaatschap, sectie kinderradiologie KBVR Koninklijke Belgische Vereniging Radiologie ; ESPR European Society of Paediatric Radiology ; IALP Dysphagia Committee Groupe de Recherche Europen du Larynx European Working Group on the Voice Handicap Index American Psychosocial Oncology Society International Psychosocial Oncology Society Committee "Screening" of the Netherlands Association of Psychosocial Oncology Dutch Society for Voice, Speech and Language Pathology International Association of Logopedics and Phoniatrics EU-AUTOROME management team EURO-RA management team steering committee EU AUTOCURE several decision boards Novartis Pharma AG.
18 ; Can an oral-fluid test be beaten? We have not found any adulterants that can beat the test at this time. Of course, donors may attempt to introduce something onto the pad or collection vial. This risk is minimized because every collection is directly and easily observed. How does the laboratory determine if the specimen is human saliva? With every specimen, the laboratory performs an IgG test. This test will determine if the specimen is human saliva and if there is sufficient saliva to perform the drug testing. The IgG test is a specimen validity test and ziprasidone.
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In contrast, fluvoxamine, fluoxetine and paroxetine have nonlinear pharmacokinetics tables 4 and 5.
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Ardiovascular diseases constitute the first cause of death in patients with chronic renal failure CRF ; 1. The main condition responsible for the high cardiac mortality in the above patients is ischaemic heart disease2, which is attributed to the markedly elevated prevalence of systemic hypertension 96% ; , diabetes mellitus DM-54% ; , low plasma HDL concentration 33% ; , elevated plasma concentrations of oxidized LDL, fibrinogen and homocysteine and finally, to the advanced age of the CRF patients3, 4. Indeed, patients with end-stage renal failure ESRF ; have a 5-20-fold greater prevalence of coronary artery disease CAD ; as compared to the general population. The prevalence of CAD is lower in patients with mild impairment of renal function 38% ; , and markedly higher in those with end-stage renal disease undergoing chronic haemodialysis or peritoneal dialysis 67% ; , especially when comorbidities such as DM ; are present2, 5, 6. Definition of chronic renal failure In most studies including patients with CRF, the variable selected for their classification into subgroups according to the degree of renal function impairment is the serum creatinine Cr ; . However, at present, an absolute consensus for the definition of CRF according to a single cut-off point for Cr serum concentration has not been established. It seems that a Cr serum concentration above 1.5 mg dL, with a Cr clearance below 60 mL min 1.73, for instance, fluoxetine fluvoxamine.
MATERIALS AND METHODS Enzymes. Restriction endonucleases and T4 DNA ligase were obtained from New England Biolabs, Beverly, Mass. Bacterial strains and plasmids. All of the bacterial strains used were derived from E. coli K-12 and are described in Table 1 or in the text. Plasmids used are described in Table 1, Fig. 3, and the text. Plasmid DNA was prepared as described by Selker et al. 31 ; . Genetic techniques. The techniques used for genetic experiments were as outlined previously 15, 17 ; . Transformations were carried out as described by Lederberg and Cohen 20 ; . TABLE 1. Strains of E. coli and plasmids used and grisactin.
| Fluvoxamine prescriptionFigure 1. Response rates to various classes of medications in a Chicago FXS cohort. Response was determined clinically based on feedback from parents, teachers, and therapists, regarding target behaviors. Stimulants included methylphenidate preparations, Adderall, and dextroamphetamine preparations. Alpha2-agonists included clonidine and guaneficine Tenex ; . Tricyclic antidepressants included imipramine and amitryptyline. SSRIs included fluoxitine Prosac ; , sertraline Zoloft ; , fluvoxamine Luvox ; , and citralopram Celexa ; . Response rates are given as a fraction of the total possible respondants for males m ; , females f ; and the total group treated with each medication class t ; . Number of individuals treated is indicated for males, females and the total group underneath the figure label for the drug category. References 1 ; Amaria RN, Billeisen LL, Hagerman RJ. Medication use in fragile X syndrome. Mental Health Asp Dev Dis 2001; 4: 89-93. ; Hagerman RJ, Murphy MA, Wittenberger MD. A controlled trial of stimulant medication in children with the fragile X syndrome. J Med Genet 1988; 30: 377-392. ; Berry-Kravis E, Grossman AW, Crnic LS, Greenough WT. Fragile X syndrome. Current Pediatrics 2002; 12: 316-324.
Who had received fluvoxamine, the resulting plasma concentrations were highly variable. Because of the small sample size, these differences could not be attributed to differences in sex, body weight, or age of the patients. The finding that a twofold increase and griseofulvin.
Sedation is generally less of a problem with fluvoxamine than with tricyclic antidepressants, but is more common than with other ssris e, g.
| Do not take fluvoamine if you have taken a monoamine oxidase mao ; inhibitor in the past 14 days and gabapentin and fluvoxamine.
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Potential interaction with thioridazine the effect of fluvxamine 25 mg bid for one week ; on thioridazine steady-state concentrations was evaluated in 10 male inpatients with schizophrenia.
It is important to keep these research limitations in mind when evaluating the outcomes of medication studies and gatifloxacin.
Figure 3 | Representative examples from different classes of antidepressant drugs. a | Prototypical tricyclic antidepressant: imipramine. b | Prototypical monoamine oxidase inhibitor: tranylcypromine. c | Selective noradrenaline reuptake inhibitor: reboxetine. d | Selective serotonin and noradrenaline reuptake inhibitors: milnacipran and venlafaxine. e | Selective serotonin reuptake activator: tianeptine. f | Selective serotonin reuptake inhibitors: citalopram, fluvoxamine, fluoxetine, paroxetine and sertraline. g | Noradrenergic and specific serotonergic antidepressant with minimal effects on monoamine reuptake: mirtazapine!
Substrates or inhibitors of cyp2c19 blood levels and or toxicity of propranolol may be increased by administration of innopran xl with substrates or inhibitors of cyp2c19, such as fluconazole, cimetidine, fluoxetine, fluvoxamine, teniposide, and tolbutamide.
The expected rate of return for both the pension and other postretirement benefit plans represents the average rate of return to be earned on plan assets over the period the benefits included in the benefit obligation are to be paid and is determined on a country basis. In developing the expected rate of return within each country, the long-term historical returns data is considered as well as actual returns on the plan assets and other capital markets experience. Using this reference information, the long-term return expectations for each asset category and a weighted average expected return for each country's target portfolio is developed, according to the allocation among those investment categories. The expected portfolio performance reflects the contribution of active management as appropriate. For 2006, the Company's expected rate of return of 8.75% will remain unchanged from 2005 for its U.S. pension and other postretirement benefit plans. The health care cost trend rate assumptions for other postretirement benefit plans are as follows.
Taking fluvoxamine, psychiatric experts and the media gave little credence to any causal connection between fl8voxamine and violence [5]. Indeed, the FDA-approved label2 for the drug seemed to give little or no indication that the drug could cause a person to commit catastrophic violence. This report will use the case of Eric Harris and the Luvox label as an example of how critically important data can be obscured or omitted even, on a government-approved drug label.
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Materials and Methods Chemicals. Supplies of cyclobenzaprine, fluoxetine, methylphenidate, prazosin, and sertraline were obtained from Pfizer Global Material Management Groton, CT ; . Citalopram, paroxetine, ritonavir, and loratadine were purchased from Sequoia Research Products Oxford, UK ; . The following reagents were purchased from the respective vendors: amiodarone Spectrum Chemical, Gardenia, CA ; , clozapine MP Biomedicals, Irvine, CA ; , fluvoxamine Tocris Cookson Inc., Ellisville, MO ; , 9-hydroxyrisperidone SynFine Research, Richmond Hill, ON, Canada ; , midazolam Cerilliant, Round Rock, TX ; , propoxyphene U.S. Pharamcopoeia, Rockville, MD ; , and venlafaxine Alchemie USA, Plantsville, CT ; . All other drugs included in the study were purchased from Sigma-Aldrich St. Louis, MO ; . Animals. Female FVB wild-type ; and mdr1a 1b , ; mice of approximately 9 weeks of age, weighing 25 to 30 g, were obtained from Taconic Farms Germantown, NY ; . For quinidine, loperamide, and caffeine, male FVB wild-type ; and mdr1a ; mice were used. Upon arrival, the mice were maintained for at least 5 days on a 12-h light dark cycle in a temperature- and humidity-controlled environment with free access to food and water. The mice were housed in clear polycarbonate boxes n 5 per box ; containing sawdust and nesting pads. The study was conducted in accordance with approved Pfizer Animal Care and Use Procedures. Drug Selection. The process of drug selection for the study was approached with the objective of identifying a representative and diverse sampling of the most commonly used CNS therapeutic agents. To identify the top-selling CNS drugs, a market assessment was conducted for total dollar sales and number of worldwide and U.S. prescriptions filled for the year 2001. To ensure chemical diversity of the data set, a structure cluster analysis was conducted. The UNITY fingerprints of CNS drugs were calculated using the software package SYBYL 6.7.1 Tripos Inc., St. Louis, MO ; and then grouped based on a hierarchical clustering algorithm. Drugs for the study were then selected based on a combination of factors including availability, market prevalence, pharmacology, chemical structure based on clustering algorithm ; , and analytical feasibility. The exercise resulted in the identification of 32 CNS drugs representing 31 distinct structure clusters. In addition, the active metabolites of risperidone and carisoprodol 9-hydroxyrisperidone and meprobamate, respectively ; were added to the study to evaluate the potential contribution of any metabolite interactions with P-gp on the biological activity of parent drug. Excluded from consideration as CNS agents were the anti-inflammatory drugs indicated for pain, and anti-migraine agents due to the peripheral location of their targeted receptors and the potential for disruption of the blood-brain barrier during migraine episodes Goadsby, 2000 ; . The CNS drugs selected represent a number of different therapeutic indications including antidepressants, sedatives, anxiolytics, tranquilizers, anticonvulsants, etc. The molecular properties of the drug set are consistent with those expected for lipophilic membrane-permeable compounds. The average molecular weight for the drug set was 297 and ranged from 141 to 426. A majority of the drugs n 24 ; were basic compounds with calculated pKa values ranging from 6.9 to 10.6. Several examples of weakly acidic or neutral drugs were represented in the data set and include: caffeine, carbamazepine, carisoprodol, diazepam, ethosuximide, meprobamate, midazolam, phenytoin, thiopental, and zolpidem. The mean calculated log D value for the CNS drug set was 1.95 and ranged from 1.12 to 4.42. The pKa and log D values were calculated using ACD labs, version 6.0 Advanced Chemistry Development Inc., Toronto, ON, Canada ; . Molecular weight and polar surface areas were calculated using MOE 2002 Chemical Computing Group, Montreal, QB, Canada ; . Overall physicochemical characteristics of the study drugs are listed in Table 1. A smaller set of eight non-CNS drugs was selected for evaluation in the study as controls. The drugs were selected for their consideration as P-gp modulators, although not necessarily as substrates for transport, and to represent a range in the degree of interaction spanning from weak or moderate to.
This study was performed to determine the effectiveness and safety of fluvoxamine for generalized sad gsad ; in japanese patients.
Pharmacokinetics Cluvoxamine is well absorbed with a bioavailability of about 50%, probably due to first-pass metabolism Table 45.7 ; . At steady state doses, fluvoxamine demonstrates non-linear pharmacokinetics over a dosage range of 100-300 mg per day, which results in higher plasma concentrations at higher doses than would be predicted by lower dose kinetics single dose 15 hours, and multiple dosing 22 hours ; . Food does not significantly affect oral bioavailability. The mean apparent volume of distribution for fluvoxamine reflects its lipophilic nature, extensive tissue distribution and protein binding. Fluvoxamin3 is distributed into breast milk. Fluvoxam8ne is preferentially metabolized by CYP2D6 in the liver by O-demethylation to its alcohol metabolite which is subsequently oxidized to a carboxylic acid. Oxidative deamination and nine other metabolites have been identified, none of which shows significant pharmacologic activity. Adverse Effects The adverse effects for fluvoxamine include symptoms of drowsiness, nausea or vomiting, abdominal pain, tremors, sinus bradycardia, and mild anticholinergic symptoms. Toxic doses could produce seizures and severe bradycardia. Drug Interactions.
In the present paper, we have compared the effects of two antidepressants: fluoxetine or fluvoxamine with three anxiolytics: buspirone, lorazepam or oxazepam on the fighting behavior deficit induced by cus procedure in rats.
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In general, studies looking at the naturalistic use of antidepressants have focused on the process or economics of treatment rather than outcome. Exceptions are two small retrospective studies of outcome in primary care. In the first of these, a study of 194 patients receiving one of the five SSRIs, no difference in outcome between the drugs was found Arias et al, 1998 ; . The second study involved 160 patients receiving fluoxetine, fluvoxamine, paroxetine or sertraline Hylan et al, 1999 ; . Patients who did not switch antidepressant or increase the dose those on stable therapy ; were 1.6 times more likely to respond than those who had a change in their regimen. Consistent with other descriptive studies, patients started on fluoxetine were more likely to have stable therapy than those on other SSRIs. Controlling for factors influencing outcome, patients on sertraline were about half as likely to respond to treatment as those on fluoxetine. There was no difference between the other SSRIs. These studies.
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Together. The dosage of one or other may need to be lowered. 2. The SSRIs, especially fluvoxamine and nefazadone can lead to elevated levels of tricyclics and cyclophosphamide. 3. Carbamazepine may lower levels of these drugs. CYP 3A4 CYP 3A4 is the most common P450 Liver Enzyme involved in psychotropic metabolism, and the table below lists medications that may interact as they are metabolised by CYP 3A4. `CYP 3A4 is the most common P450 Liver Enzyme involved in psychotropic metabolism' Astimozole, alprazolam and cisapride are all substrates of the CYP3A4 enzyme. Carbamazepine is an inducer i.e. increases the activity of CYP3A4 and therefore may reduce levels of drugs metabolised by CYP3A4. Grapefruit juice is also a potent inhibitor and St John's Wort is a potent inducer.
Ray Walsh INTRODUCTION Based on the Agent Orange Act of 1991, the Department of Veterans Affairs VA ; has determined that a positive association exists between exposure to herbicides and the subsequent development of adenocarcinoma of the prostate. Manifestation of prostate cancer in veterans who served in Vietnam between January 9, 1962 and May 5, 1975 is considered a service-related disability for which they should be compensated. A veteran qualifies no matter when this disease appears following a tour in Vietnam. The act also established the positive association with ten other health conditions. In a recent development, Navy and Coast Guard personnel who served aboard ships off the Vietnamese coast so-called "Blue Water Navy" ; are seeking inclusion in the Agent Orange program; more about this later. There is no time requirement when symptoms of the disease have to appear. Timeliness of the claim submission is of significant importance in determining the amount of compensation. A compensation application submitted immediately upon diagnosis of prostate cancer, prior to any treatment, could initially result in a 100 percent disability rating for at least six months. Additionally, military retirees who receive a VA disability rating for Agent Orange related-prostate cancer may be eligible for compensation in the form of Combat Related Special Compensation CRSC ; , or Concurrent Retirement and Disability Pay CRDP ; administered separately by the Military Services. DISABILITY COMPENSATION FOR AGENT ORANGE-DERIVED PROSTATE CANCER To receive disability compensation, a veteran must submit a Veteran's Application for Compensation or Pension VA Form 21-526 ; . If a veteran is receiving disability compensation for other conditions, a request for amended disability may be submitted in a letter application which documents the new disability. The claim is effective from the date of submission. When approved, payment of compensation begins the first day of the month following the submission date. The dollar value of compensation granted will be based on the disability rating awarded by the VA. There are no provisions for retroactive payments prior to the claim submission date. Continued on page 9.
The therapeutic evaluation consisted of a meta-analysis that compared i ; efficacy, ii ; completion rates, and iii ; adverse effects of individual drugs and drug classes. The individual drugs were by drug class ; : SSRIs - Fluoxetine, Fluvoxamine, Paroxetine, Sertraline TCAs -Amitriptyline, Imipramine, Clomipramine, Dothiepin, Doxepin, Maprotiline, Oxaprotiline, Lofepramine, Desipramine, Nortriptyline Other antidepressants1 - Mianserin, Trazodone, Moclobemide, Bupropion, Amineptine, Nomifensine.
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