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Following Pfizer's announcement Jan. 22 that it would close its research and development operations in Ann Arbor and Kalamazoo, perhaps one of the questions most frequently asked was: why Michigan? Rick Chambers, director of corporate media relations for Pfizer, said there was no one reason that Michigan was hit so hard. "That is the question everybody's been asking and it can't really be boiled down to we kept this site because of X and eliminated this site because of Y, " Chambers said. "I will say, however, that it had become painfully clear to Pfizer that the company needs to be more focused in a less-costly way and that included a need to consolidate a major site." In a presentation to analysts and investors Monday, John LaMattina, president of Pfizer Global Research and Development, said the company is changing where and how it works. Part of the plan consists of reducing the footprint of the company's research and development operations. The company said that in 2003 it had 20 million square feet at 25 sites in 10 countries. The largest U.S. complex is in Groton, Mass., where the company employs more than 5, 000. Groton was not part of any announced cuts, though research and development centers in Nagoya, Japan, and Amboise, France, also are to be closed and another center in Germany is scheduled to be sold. Manufacturing centers in Brooklyn, N.Y., and Omaha, Neb., also are to be closed. The company said it wants to cut its square footage in half and shift money used in bricks and mortar projects to product development and invest in research companies like Esperion Therapeutics Inc., which it bought in 2004. The company wants to reduce research and development spent on support staff and facilities by more than 20 percent. LaMattina said the company needs to change its research and development process by creating smaller, more-agile research units that are more productive and able to meet the company's goal of introducing four new drugs a year by 2011. -- Andrew Dietderich levels. It also means applying technologies developed by the auto industry to life sciences, as and warfarin!

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